Isomeric Activity Cliffs-A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands

Pietrus, W; Kurczab, R; Warszycki, D; Bojarski, AJ; Bajorath, J

Kurczab, R (通讯作者),Polish Acad Sci, Maj Inst Pharmacol, Dept Med Chem, Smetna 12, PL-31343 Krakow, Poland.

MOLECULES, 2023; 28 (2):

Abstract

Currently, G protein-coupled receptors (GPCRs) constitute a significant group of membrane-bound receptors representing more than 30% of therapeutic ta......

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