The role of propofol hydroxyl group in 5-lipoxygenase recognition

Yuki, K; Bu, WM; Eckenhoff, RG; Yokomizo, T; Okuno, T

Yuki, K (corresponding author), Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, 300 Longwood Ave, Boston, MA 02115 USA.; Okuno, T (corresponding author), Juntendo Univ, Fac Med, Dept Biochem, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020; 525 (4): 909

Abstract

Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for ......

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