Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non-small cell lung cancer

He, DH; Chen, YF; Zhou, YL; Zhang, SB; Hong, M; Yu, XJ; Wei, SF; Fan, XZ; Li, SY; Wang, Q; Lu, YZ; Liu, YQ

Liu, YQ (corresponding author), Guangzhou Univ Chinese Med, 232 Waihuan East Rd, Guangzhou 510006, Peoples R China.; Lu, YZ (corresponding author), Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave, Guangzhou 510005, Peoples R China.

CANCER SCIENCE, 2021; 112 (8): 3218

Abstract

Skp2 is overexpressed in multiple cancers and plays a critical role in tumor development through ubiquitin/proteasome-dependent degradation of its sub......

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