Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

Tan, XH; Tong, L; Li, L; Xu, JJ; Xie, SF; Ji, L; Fu, JJ; Liu, QW; Shen, SH; Liu, Y; Xiao, YH; Gao, FR; Moses, RE; Bardeesy, N; Wang, YX; Zhang, JS; Tang, LY; Li, L; Wong, KK; Song, DW; Yang, X; Liu, J; Li, XT

Yang, X (corresponding author), Beijing Inst LifeOm, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing, Peoples R China.; Li, XT (corresponding author), East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Sch Life Sci, Shanghai, Peoples R China.; Li, XT (corresponding author), Southwest Med Univ, Res Ctr Preclin Med, Key Lab Epigenet & Oncol, Luzhou, Sichuan, Peoples R China.; Liu, J (corresponding author), Zhejiang Univ, Sch Med, Zhejiang U

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

SMAD4 is mutated in human lung cancer, but the underlying mechanism by which Smad4 loss-of-function (LOF) accelerates lung cancer metastasis is yet to......

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