Proliferation of PD-1+CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients

Kamphorst, AO; Pillai, RN; Yang, S; Nasti, TH; Akondy, RS; Wieland, A; Sica, GL; Yu, K; Koenig, L; Patel, NT; Behera, M; Wu, H; McCausland, M; Chen, ZJ; Zhang, C; Khuri, FR; Owonikoko, TK; Ahmed, R; Ramalingam, SS

Ahmed, R (reprint author), Emory Univ, Sch Med, Dept Microbiol & Immunol, Emory Vaccine Ctr, Atlanta, GA 30322 USA.; Ramalingam, SS (reprint author), Emory Univ, Sch Med, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017; 114 (19): 4993

Abstract

Exhausted T cells in chronic infections and cancer have sustained expression of the inhibitory receptor programmed cell death 1 (PD-1). Therapies that......

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