Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

Ruffo, E; Butchy, AA; Tivon, Y; So, V; Kvorjak, M; Parikh, A; Adams, EL; Miskov-Zivanov, N; Finn, OJ; Deiters, A; Lohmueller, J

Lohmueller, J (通讯作者)，Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA 15260 USA.;Lohmueller, J (通讯作者)，Univ Pittsburgh, Div Surg Oncol, Dept Surg, Pittsburgh, PA 15260 USA.;Lohmueller, J (通讯作者)，Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA.;Lohmueller, J (通讯作者)，Univ Pittsburgh, Ctr Syst Immunol, Pittsburgh, PA 15260 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respo......

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