HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir

Yasutake, Y; Hattori, S; Hayashi, H; Matsuda, K; Tamura, N; Kohgo, S; Maeda, K; Mitsuya, H

Yasutake, Y (reprint author), Natl Inst Adv Ind Sci & Technol, Bioprod Res Inst, Sapporo, Hokkaido 0628517, Japan.; Maeda, K (reprint author), Natl Ctr Global Hlth, Tokyo 1628655, Japan.; Maeda, K (reprint author), Med Res Inst, Tokyo 1628655, Japan.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Hepatitis B virus (HBV) reverse transcriptase (RT) is essential for viral replication and is an important drug target. Nonetheless, the notorious inso......

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