Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates

Zhang, B; Hu, XT; Gu, J; Yang, YS; Duan, YT; Zhu, HL

Yang, YS; Zhu, HL (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China.; Duan, YT (corresponding author), Zhengzhou Univ, Childrens Hosp, Henan Prov Key Lab Childrens Genet & Metab Dis, Zhengzhou 450018, Peoples R China.

BIOORGANIC CHEMISTRY, 2020; 105 ():

Abstract

As an essential enzyme with a variety of physiological functions, Cyclooxygenase-2 (COX-2) is also closely related to carcinoma due to the observed ov......

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