Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

Zhu, YH; He, X; Lin, YC; Dong, HJ; Zhang, L; Chen, XW; Wang, ZH; Shen, YD; Li, M; Wang, HY; Sun, J; Nguyen, LX; Zhang, H; Jiang, WJ; Yang, YZ; Chen, JJ; Muschen, M; Chen, CW; Konopleva, MY; Sun, WL; Jin, J; Carlesso, N; Marcucci, G; Luo, Y; Li, L

Li, L (reprint author), City Hope Med Ctr, Dept Hematol Malignancies Translat Sci, Gehr Family Ctr Leukemia Res,Beckman Res Inst, Hematol Malignancies & Stem Cell Transplantat Ins, 1500 E Duarte Rd, Duarte, CA 91010 USA.

BLOOD, 2019; 134 (15): 1257

Abstract

Relapse remains the main cause of MLL-rearranged (MLL-r) acute lymphoblastic leukemia (ALL) treatment failure resulting from persistence of drug-resis......

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