Targeting MCOLN1/TRPML1 channels to protect against ischemia-reperfusion injury by restoring the inhibited autophagic flux in cardiomyocytes

Sui, ZH; Wang, MM; Xing, YH; Qi, JS; Wang, WY

Qi, JS; Wang, WY (通讯作者),Xuzhou Med Univ, Jiangsu Prov Key Lab Anesthesiol, Jiangsu Prov Key Lab Anesthesia & Analgesia Appli, Key Lab Res & Evaluat Narcot & Psychotrop Drugs, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China.

AUTOPHAGY, 2022; 18 (12): 3053

Abstract

Accumulating evidence suggests that macroautophagy/autophagy dysfunction plays a critical role in myocardial ischemia-reperfusion (I/R) injury. Howeve......

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