Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

Konteatis, Z; Artin, E; Nicolay, B; Straley, K; Padyana, AK; Jin, L; Chen, Y; Narayaraswamy, R; Tong, SL; Wang, F; Zhou, D; Cui, DW; Cai, ZW; Luo, ZY; Fang, C; Tang, HC; Lv, XB; Nagaraja, R; Yang, H; Su, SS; Sui, ZH; Dang, L; Yen, K; Popovici-Muller, J; Codega, P; Campos, C; Mellinghoff, IK; Biller, SA

Biller, SA (corresponding author), Agios Pharmaceut Inc, Cambridge, MA 02139 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (2): 101

Abstract

Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes prevent the accumulation of the oncometabolite D-2-hydroxygluta......

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