Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia

Campbell, CT; Haladyna, JN; Drubin, DA; Thomson, TM; Maria, MJ; Yamauchi, T; Waters, NJ; Olhava, EJ; Pollock, RM; Smith, JJ; Copeland, RA; Blakemore, SJ; Bernt, KM; Daigle, SR

Daigle, SR (reprint author), Epizyme Inc, 400 Technol Sq,4th Floor, Cambridge, MA 02139 USA.

MOLECULAR CANCER THERAPEUTICS, 2017; 16 (8): 1669

Abstract

DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its ectopic methylation of......

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