Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket

Lu, Y; Liu, HY; Yang, DH; Zhong, L; Xin, Y; Zhao, SW; Wang, MW; Zhou, QT; Shui, WQ

Shui, WQ (corresponding author), ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.; Wang, MW; Shui, WQ (corresponding author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.; Wang, MW (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, MW (corresponding author), Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Wang, MW (corresponding author), Chinese Acad Sci, CAS

ACS CHEMICAL BIOLOGY, 2021; 16 (6): 991

Abstract

Allosteric ligands provide new opportunities to modulate G protein-coupled receptor (GPCR) function and present therapeutic benefits over orthosteric ......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索