HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma

Courtney, KD; Ma, YQ; de Leon, AD; Christie, A; Xie, ZQ; Woolford, L; Singla, N; Joyce, A; Hill, H; Madhuranthakam, AJ; Yuan, Q; Xi, Y; Zhang, Y; Chang, J; Fatunde, O; Arriaga, Y; Frankel, AE; Kalva, S; Zhang, S; McKenzie, T; Torras, OR; Figlin, RA; Rini, BI; McKay, RM; Kapur, P; Wang, T; Pedrosa, I; Brugarolas, J

CLINICAL CANCER RESEARCH, 2020; 26 (4): 793

Abstract

Purpose: The heterodimeric transcription factor HIF-2 is arguably the most important driver of clear cell renal cell carcinoma (ccRCC). Although consi......

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