Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity

Dalton, R; Lee, SB; Claw, KG; Prasad, B; Phillips, BR; Shen, DD; Wong, LH; Fade, M; McDonald, MG; Dunham, MJ; Fowler, DM; Rettie, AE; Schuetz, E; Thornton, TA; Nickerson, DA; Gaedigk, A; Thummel, KE; Woodahl, EL

Woodahl, EL (reprint author), Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (1): 147

Abstract

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural va......

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