Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Yang, N; Wang, Y; Dai, PH; Li, T; Zierhut, C; Tan, A; Zhang, T; Xiang, JZ; Ordureau, A; Funabiki, H; Chen, ZJ; Deng, L

Yang, N; Deng, L (通讯作者)，Mem Sloan Kettering Canc Ctr, Dept Med, Dermatol Serv, New York, NY 10065 USA.;Deng, L (通讯作者)，Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA.;Deng, L (通讯作者)，Weill Cornell Med Coll, New York, NY 10065 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belo......

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