sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

Hall, KC; Bernier, SG; Jacobson, S; Liu, G; Zhang, PY; Sarno, R; Catanzano, V; Currie, MG; Masferrer, JL

Hall, KC (reprint author), Ironwood Pharmaceut, Cambridge, MA 02142 USA.; Hall, KC (reprint author), Cycler Therapeut, Cambridge, MA 02142 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (22): 11057

Abstract

Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimu......

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