KRAS(G12C)-independent feedback activation of wild-type RAS constrains KRAS(G12C) inhibitor efficacy

Ryan, MB; Coker, O; Sorokin, A; Fella, K; Barnes, H; Wong, E; Kanikarla, P; Gao, F; Zhang, YY; Zhou, L; Kopetz, S; Corcoran, RB

Corcoran, RB (通讯作者),Massachusetts Gen Hosp, Ctr Canc, 149 13th St,7th Floor, Boston, MA 02129 USA.;Corcoran, RB (通讯作者),Harvard Med Sch, Dept Med, Boston, MA 02115 USA.

CELL REPORTS, 2022; 39 (12):

Abstract

Although KRAS has long been considered undruggable, direct KRAS(G12C) inhibitors have shown promising initial clinical efficacy. However, the majority......

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