Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

McKenzie, C; El-Kholy, M; Parekh, F; Robson, M; Lamb, K; Allen, C; Sillibourne, J; Cordoba, S; Thomas, S; Pule, M

Pule, M (通讯作者),Autolus Therapeut, London W12 7FP, England.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2023; 32 (): 603

Abstract

The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor ini-tiates apoptosis and disru......

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