A novel antifolate suppresses growth of FPGS-deficient

van der Krift, F; Zijlmans, DW; Shukla, R; Javed, A; Koukos, PI; Schwarz, LL; Timmermans-Sprang, EP; Maas, PE; Gahtory, D; van den Nieuwboer, M; Mol, JA; Strous, GJ; Bonvin, AM; van der Stelt, M; Veldhuizen, EJ; Weingarth, M; Vermeulen, M; Klumperman, J; Maurice, MM

Maurice, MM (通讯作者),Univ Med Ctr Utrecht, Ctr Mol Med, Utrecht, Netherlands.;Maurice, MM (通讯作者),Univ Med Ctr Utrecht, Oncode Inst, Utrecht, Netherlands.

LIFE SCIENCE ALLIANCE, 2023; 6 (11):

Abstract

Cancer cells make extensive use of the folate cycle to sustain increased anabolic metabolism. Multiple chemotherapeutic drugs interfere with the folat......

Full Text Link