Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes

Song, HK; Li, HX; Guo, SM; Pan, YY; Fu, YH; Zhou, ZJ; Li, ZY; Wen, X; Sun, XL; He, BQ; Gu, HF; Zhao, Q; Wang, C; An, P; Luo, SQ; Hu, YH; Xie, X; Lu, BX

Lu, BX (reprint author), Fudan Univ, State Key Lab Med Neurobiol, Sch Life Sci, Neurol Dept,Huashan Hosp, Shanghai, Peoples R China.; Xie, X (reprint author), Chinese Acad Sci, CAS Key Lab Receptor Res, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shan

BRAIN, 2018; 141 (): 1782

Abstract

Lowering the levels of disease-causing proteins is an attractive treatment strategy for neurodegenerative disorders, among which Huntington's disease ......

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