Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Pietrobono, S; Stecca, B

Stecca, B (reprint author), Inst Canc Res Prevent & Clin Network ISPRO, Core Res Lab, Tumor Cell Biol Unit, I-50139 Florence, Italy.

CELLS, 2018; 7 (12):

Abstract

Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude o......

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