Exposure-Response Modeling and Power Analysis of Components of ACR Response Criteria in Rheumatoid Arthritis (Part 2: Continuous Model)

Li, L; Zhang, Y; Ma, L; Ji, P; Yim, S; Chowdhury, BA; Doddapaneni, S; Liu, J; Wang, YN; Sahajwalla, C

Ji, P (reprint author), US FDA, Div Clin Pharmacol 2, Off Clin Pharmacol, Ctr Drug Evaluat & Res, WO51 RM 3144,10903 New Hampshire Ave, Silver Spring, MD 20993 USA.

JOURNAL OF CLINICAL PHARMACOLOGY, 2017; 57 (9): 1107

Abstract

Population pharmacokinetic/pharmacodynamic (PK/PD) models were developed to quantitate the exposure-response relationships using continuous longitudin......

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