Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

Martínez-Sena, T; Moro, E; Moreno-Torres, M; Quintás, G; Hengstler, J; Castell, JV

Castell, JV (通讯作者),Inst Invest Sanitaria Hosp La Fe IIS La Fe, Unidad Mixta Hepatol Expt, Valencia, Spain.;Castell, JV (通讯作者),Univ Valencia, Fac Med, Dept Bioquim & Biol Mol, Valencia, Spain.;Castell, JV (通讯作者),Inst Salud Carlos III, CIBEREHD, Madrid, Spain.;Castell, JV (通讯作者),Hlth Res Inst La Fe, Analyt Unit, Valencia, Spain.

ARCHIVES OF TOXICOLOGY, 2023; 97 (6): 1723

Abstract

Toxicity studies, among them hepatotoxicity, are key throughout preclinical stages of drug development to minimise undesired toxic effects that might ......

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