Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma

Ma, WJ; Wang, YL; Zhang, RX; Yang, F; Zhang, D; Huang, MG; Zhang, L; Dorsey, JF; Binder, ZA; O'Rourke, DM; Fraietta, JA; Gong, YQ; Fan, Y

Fan, Y (corresponding author), Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA.; Fan, Y (corresponding author), Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA.; Fan, Y (corresponding author), Univ Penn, Abramson Canc Ctr, Glioblastoma Translat Ctr Excellence, Philadelphia, PA 19104 USA.; Gong, YQ (corresponding author), Univ Penn, Dept Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA.

NATURE CANCER, 2021; 2 (1): 83

Abstract

Malignant solid tumors are characterized by aberrant vascularity that fuels the formation of an immune-hostile microenvironment and induces resistance......

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