delta-Secretase-cleaved Tau stimulates A beta production via upregulating STAT1-BACE1 signaling in Alzheimer's disease

Zhang, ZT; Li, XG; Wang, ZH; Song, MK; Yu, SP; Kang, SS; Liu, X; Zhang, ZH; Xie, ML; Liu, GP; Wang, JZ; Ye, KQ

Ye, KQ (corresponding author), Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.; Wang, JZ (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Minist Educ China Neurol Disorders, Pathophysiol Dept,Key Lab, Wuhan 430030, Peoples R China.; Wang, JZ (corresponding author), Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China.; Ye, KQ (corresponding author), Tongji Univ, Tongji Hosp, Sch Med, Shanghai 200065, Peoples R China.

MOLECULAR PSYCHIATRY, 2021; 26 (2): 586

Abstract

delta-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neu......

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