Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies

Xiang, J; Wang, ZH; Ahn, EH; Liu, X; Yu, SP; Manfredsson, FP; Sandoval, IM; Ju, G; Wu, SX; Ye, KQ

Ye, KQ (reprint author), Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (18): 9094

Abstract

BDNF, an essential trophic factor implicated in synaptic plasticity and neuronal survival, is reduced in Alzheimer's disease (AD). BDNF deficiency's a......

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