Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Golombek, S; Hoffmann, T; Hann, L; Mandler, M; Schmidhuber, S; Weber, J; Chang, YT; Mehling, R; Ladinig, A; Knecht, C; Leyens, J; Schlensak, C; Wendel, HP; Schneeberger, A; Avci-Adali, M

Avci-Adali, M (通讯作者)，Univ Hosp Tubingen, Dept Thorac & Cardiovasc Surg, Calwerstr 7-1, D-72076 Tubingen, Germany.;Avci-Adali, M (通讯作者)，Univ Hosp Tubingen, Dept Thorac & Cardiovasc Surg, Calwerstr 7-1, D-72076 Tubingen, Germany.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2023; 33 (): 642

Abstract

Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investiga......

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