In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing

Wang, Y; Cheng, HJ; Liu, Y; Liu, Y; Wen, X; Zhang, K; Ni, XM; Gao, N; Fan, LW; Zhang, ZH; Liu, J; Chen, JZ; Wang, LX; Guo, YM; Zheng, P; Wang, M; Sun, JB; Ma, YH

Wang, Y; Zheng, P; Wang, M (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China.; Wang, Y; Zheng, P; Wang, M (corresponding author), Natl Technol Innovat Ctr Synthet Biol, Tianjin, Peoples R China.; Wang, Y; Zheng, P; Wang, M (corresponding author), Univ Chinese Acad Sci, Beijing, Peoples R China.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

Reprogramming complex cellular metabolism requires simultaneous regulation of multigene expression. Ex-situ cloning-based methods are commonly used, b......

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