Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

Zhao, N; Cao, J; Xu, LY; Tang, QZ; Dobrolecki, LE; Lv, XD; Talukdar, M; Lu, Y; Wang, XR; Hu, DZ; Shi, Q; Xiang, Y; Wang, YF; Liu, X; Bu, W; Jiang, Y; Li, MZ; Gong, YY; Sun, Z; Ying, HQ; Yuan, B; Lin, X; Feng, XH; Hartig, SM; Li, F; Shen, HF; Chen, YW

Chen, X (reprint author), Dept Mol & Cellular Biol, One Baylor Plaza,MS BCM130,Debakey Bldg,BCMM M626, Houston, TX 77030 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2018; 128 (4): 1283

Abstract

The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated in many human cancers and plays pivotal roles in tumor progr......

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