Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBP alpha/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation

Parafati, M; Bae, SH; Kirby, RJ; Fitzek, M; Iyer, P; Engkvist, O; Smith, DM; Malany, S

Malany, S (corresponding author), Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA.; Malany, S (corresponding author), Sanford Burnham Prebys Med Discovery Inst, Conrad Prebys Ctr Chem Genom, La Jolla, CA 92037 USA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (24):

Abstract

Non-alcoholic fatty liver disease (NAFLD) has a large impact on global health. At the onset of disease, NAFLD is characterized by hepatic steatosis de......

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