MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor- suppressive function by upregulating ZEB2 in NSCLC

Zhao, KQ; Zheng, MY; Su, ZZ; Ghosh, S; Zhang, C; Zhong, WZ; Ho, JWK; Jin, GX; Zhou, ZJ

Jin, GX; Zhou, ZJ (通讯作者)，Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Med Res Ctr, Guangzhou 510080, Peoples R China.;Zhou, ZJ (通讯作者)，Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China.;Zhou, ZJ (通讯作者)，Chinese Acad Sci, Hong Kong Inst Sci & Innovat, Ctr Regenerat Med & Hlth, Hong Kong, Peoples R China.;Zhou, ZJ (通讯作者)，Univ Hong Kong, Reprod Med Ctr, Shenzhen Hosp, Shenzhen, Peoples R China.

CELL REPORTS, 2023; 42 (8):

Abstract

Mammalian sirtuin 6 (SIRT6) regulates a spectrum of vital biological processes and has long been implicated in the progression of cancer. However, the......

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