A gain-of-function NLRP3 3 '-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression

Lu, FR; Chen, HP; Hong, Y; Lin, Y; Liu, LZ; Wei, N; Wu, QY; Liao, SL; Yang, S; He, JB; Shao, YM

Shao, YM (corresponding author), Guangdong Med Univ, Affiliated Hosp 2, Intens Care Unit, Key Lab Sepsis Translat Med, Minyou Rd 12, Zhanjiang City 524001, Guangdong, Peoples R China.; He, JB (corresponding author), SunYat Sen Univ, Jieyang Affiliated Hosp, Intens Care Unit, Clin Med Res Lab, Tianfu Rd 107, Jieyang City 522000, Guangdong, Peoples R China.; Shao, YM (corresponding author), Guangdong Med Univ, Intens Care Unit, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China.; Shao, YM (cor

SCIENTIFIC REPORTS, 2021; 11 (1):

Abstract

Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines......

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