Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice

Yuan, M; Hu, WJ; Feng, YY; Tong, Y; Wang, X; Tan, B; Xu, H; Liu, J

Xu, H (通讯作者)，Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China.;Liu, J (通讯作者)，Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.

BIOMEDICAL CHROMATOGRAPHY, 2022; 36 (7):

Abstract

Remdesivir (RDV), a phosphoramidate prodrug, has broad-spectrum antiviral activity. It is the first antiviral drug approved by the US Food and Drug Ad......

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