Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma

Leung, GP; Feng, TS; Sigoillot, FD; Geyer, FC; Shirley, MD; Ruddy, DA; Rakiec, DP; Freeman, AK; Engelman, JA; Jaskelioff, M; Stuart, DD

Jaskelioff, M (reprint author), Novartis Inst BioMed Res, Oncol, Cambridge, MA 02139 USA.; Stuart, DD (reprint author), Novartis Inst BioMed Res, 250 Massachusetts Ave, Cambridge, MA 02139 USA.

MOLECULAR CANCER RESEARCH, 2019; 17 (1): 199

Abstract

The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF-MEK-ERK signaling pathway addictio......

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