A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome

Zhao, L; Yang, W; Chen, Y; Huang, FJ; Lu, L; Lin, CY; Huang, T; Ning, ZW; Zhai, LX; Zhong, LLD; Lam, WC; Yang, Z; Zhang, X; Cheng, C; Han, LJ; Qiu, QW; Shang, XX; Huang, RY; Xiao, HT; Ren, ZX; Chen, DF; Sun, SL; El-Nezami, H; Cai, ZW; Lu, AP; Fang, XD; Jia, W; Bian, ZX

Jia, W (corresponding author), Univ Hawaii, Canc Ctr, Canc Biol Program, 701 Ilalo St, Honolulu, HI 96813 USA.; Bian, ZX (corresponding author), Chinese Med Clin Study Ctr, Sch Chinese Med, Inst Brain & Gut Res, Kowloon, 7 Hong Kong Baptist Univ Rd, Hong Kong, Peoples R China.; Fang, XD (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Bioinformat Grp, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.

JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1): 438

Abstract

An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the fac......

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