Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model

Thankan, RS; Thomas, E; Purushottamachar, P; Weber, DJ; Njar, VCO

Njar, VCO (通讯作者)，Univ Maryland, Sch Med, Dept Pharmacol, 685 West Baltimore St, Baltimore, MD 21201 USA.;Njar, VCO (通讯作者)，Univ Maryland, Sch Med, Ctr Biomol Therapeut, 685 West Baltimore St, Baltimore, MD 21201 USA.;Njar, VCO (通讯作者)，Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, 685 West Baltimore St, Baltimore, MD 21201 USA.;Njar, VCO (通讯作者)，Isoprene Pharmaceut Inc, 801 West Baltimore St,Suite 502J, Baltimore, MD 21201 USA.

BIOORGANIC CHEMISTRY, 2023; 139 ():

Abstract

Galeterone, 3 beta-(hydroxy)-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (Gal, 1) and VNPP433-3 beta, 3 beta-(1Himidazole-1-yl-17-(1H-benzimidazole-......

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