Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens

Schlabach, MR; Lin, S; Collester, ZR; Wrocklage, C; Shenker, S; Calnan, C; Xu, TL; Gannon, HS; Williams, LJ; Thompson, F; Dunbar, PR; Lamothe, RA; Garrett, TE; Colletti, N; Hohmann, AF; Tubo, NJ; Bullock, CP; Le Mercier, I; Sofjan, K; Merkin, JJ; Keegan, S; Kryukov, GV; Dugopolski, C; Stegmeier, F; Wong, KR; Sharp, FA; Cadzow, L; Benson, MJ

Benson, MJ (通讯作者)，KSQ Therapeut, Lexington, MA USA.;Benson, MJ (通讯作者)，KSQ Therapeut, 4 Maguire Rd, Lexington, MA 02421 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (24):

Abstract

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with ......

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