EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Pearson, JS; Giogha, C; Muhlen, S; Nachbur, U; Pham, CLL; Zhang, Y; Hildebrand, JM; Oates, CV; Lung, TWF; Ingle, D; Dagley, LF; Bankovacki, A; Petrie, EJ; Schroeder, GN; Crepin, VF; Frankel, G; Masters, SL; Vince, J; Murphy, JM; Sunde, M; Webb, AI; S

Hartland, EL (reprint author), Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia.

NATURE MICROBIOLOGY, 2017; 2 (4):

Abstract

Cell death signalling pathways contribute to tissue homeostasis and provide innate protection from infection. Adaptor proteins such as receptor-intera......

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