4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice

Alfahel, L; Argueti-Ostrovsky, S; Barel, S; Saleh, MA; Kahn, J; Azoulay-Ginsburg, S; Rothstein, A; Ebbinghaus, S; Gruzman, A; Israelson, A

Israelson, A (通讯作者)，Ben Gurion Univ Negev, Dept Physiol & Cell Biol, POB 653, IL-8410501 Beer Sheva, Israel.;Israelson, A (通讯作者)，Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, POB 653, IL-8410501 Beer Sheva, Israel.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022; 23 (16):

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons. Mutations in the superoxi......

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