Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

Xia, M; Liu, J; Liu, SX; Chen, K; Lin, HY; Jiang, MH; Xu, XQ; Xue, YQ; Liu, W; Gu, Y; Zhang, X; Li, ZQ; Yi, L; Qian, YC; Zhou, C; Li, R; Zhang, X; Li, ZG; Cao, XT

Cao, XT (reprint author), Chinese Acad Med Sci, Peking Union Med Coll, Dept Immunol, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China.; Cao, XT (reprint author), Chinese Acad Med Sci, Peking Union Med Coll, Ctr Immunotherapy, Inst Basic Med Sci,

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

Regulatory T (Treg) cells are important for the maintenance of immune homoeostasis and prevention of autoimmune diseases. Epigenetic modifications hav......

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