MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM

Casaletto, JB; Geddie, ML; Abu-Yousif, AO; Masson, K; Fulgham, A; Boudot, A; Maiwald, T; Kearns, JD; Kohli, N; Su, S; Razlog, M; Raue, A; Kalra, A; Hakansson, M; Logan, DT; Welin, M; Chattopadhyay, S; Harms, BD; Nielsen, UB; Schoeberl, B; Lugovskoy,

Raue, A; MacBeath, G (reprint author), Merrimack Pharmaceut Inc, Discovery Div, Cambridge, MA 02139 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (15): 7533

Abstract

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as ME......

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