Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors

Bass, AKAS; Nageeb, EM; El-Zoghbi, MS; Mohamed, MFA; Badr, M; Abuo-Rahma, GEA

Abuo-Rahma, GEA (通讯作者)，Minia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt.;Abuo-Rahma, GEA (通讯作者)，Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia, Al Minya, Egypt.

BIOORGANIC CHEMISTRY, 2022; 119 ():

Abstract

Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-cyanopyridines as a novel cap moiety linked with aliphatic......

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