Blockade of deubiquitinase YOD1 degrades oncogenic PML/RAR alpha and eradicates acute promyelocytic leukemia cells

Shao, XJ; Chen, YQ; Wang, W; Du, WX; Zhang, XY; Cai, MY; Bing, SW; Cao, J; Xu, XJ; Yang, B; He, QJ; Ying, MD

Ying, MD (通讯作者)，Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Peoples R China.;Ying, MD (通讯作者)，Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med, Hangzhou 310052, Peoples R China.;Ying, MD (通讯作者)，Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China.

ACTA PHARMACEUTICA SINICA B, 2022; 12 (4): 1856

Abstract

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor alpha (RAR alpha) due to chromosomal tr......

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