Targeting the CALR interactome in myeloproliferative neoplasms

Pronier, E; Cifani, P; Merlinsky, TR; Berman, KB; Somasundara, AVH; Rampal, UK; LaCava, J; Wei, KE; Pastore, F; Maag, JLV; Park, J; Koche, R; Kentsis, A; Levine, RL

Levine, RL (reprint author), Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, Box 20, New York, NY 10065 USA.

JCI INSIGHT, 2018; 3 (22):

Abstract

Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL)......

Full Text Link