BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

Samelson, AJ; Tran, QD; Robinot, R; Carrau, L; Rezelj, VV; Mac Kain, A; Chen, M; Ramadoss, GN; Guo, XY; Lim, SA; Lui, I; Nunez, JK; Rockwood, SJ; Wang, JH; Liu, N; Carlson-Stevermer, J; Oki, J; Maures, T; Holden, K; Weissman, JS; Wells, JA; Conklin, BR; TenOever, BR; Chakrabarti, LA; Vignuzzi, M; Tian, RL; Kampmann, M

Tian, RL; Kampmann, M (通讯作者),Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.;Tian, RL; Kampmann, M (通讯作者),Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.;Tian, RL (通讯作者),Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China.;Kampmann, M (通讯作者),Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA.

NATURE CELL BIOLOGY, 2022; 24 (1): 24

Abstract

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted ......

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