CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Venkatanarayan, A; Liang, J; Yen, I; Shanahan, F; Haley, B; Phu, L; Verschueren, E; Hinkle, TB; Kan, D; Segal, E; Long, JE; Lima, T; Liau, NPD; Sudhamsu, J; Li, J; Klijn, C; Piskol, R; Junttila, MR; Shaw, AS; Merchant, M; Chang, MT; Kirkpatrick, DS; Malek, S

Malek, S (通讯作者)，Genentech Inc, Dept Discovery Oncol, 1 DNA Way, San Francisco, CA 94080 USA.

CELL REPORTS, 2022; 38 (6):

Abstract

KRAS, which is mutated in-30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but......

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