The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Schneider, KS; Gross, CJ; Dreier, RF; Saller, BS; Mishra, R; Gorka, O; Heilig, R; Meunier, E; Dick, MS; Cikovic, T; Sodenkamp, J; Medard, G; Naumann, R; Ruland, J; Kuster, B; Broz, P; Gross, O

Gross, O (reprint author), Tech Univ Munich, Inst Clin Chem & Pathobiochem, Sch Med, Klinikum Rechts Isar, D-81675 Munich, Germany.; Gross, O (reprint author), Univ Freiburg, BIOSS Ctr Biol Signaling Studies, D-79104 Freiburg, Germany.; Gross, O (reprint

CELL REPORTS, 2017; 21 (13): 3846

Abstract

Inflammasomes activate the protease caspase-1, which cleaves interleukin-1 beta and interleukin-18 to generate the mature cytokines and controls their......

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