p21(WAF1/CIP1) promotes p53 protein degradation by facilitating p53-Wip1 and p53-Mdm2 interaction

Lee, J; Kim, J; Kim, EM; Kim, U; Kang, AR; Park, JK; Um, HD

Um, HD (corresponding author), Korea Inst Radiol & Med Sci, Div Radiat Biomed Res, Nowon Ro 75, Seoul 01812, South Korea.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 543 (): 23

Abstract

Downregulation of the p53 tumor suppressor in cancers is frequently accompanied by the upregulation of Wip1 (a phosphatase) and Mdm2 (an E3 ubiquitin ......

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