NGR-TNF Engineering with an N-Terminal Serine Reduces Degradation and Post-Translational Modifications and Improves Its Tumor-Targeting Activity

Corti, A; Gasparri, AM; Sacchi, A; Colombo, B; Monieri, M; Rrapaj, E; Ferreri, AJM; Curnis, F

Corti, A (corresponding author), Univ Vita Salute San Raffaele, I-20132 Milan, Italy.; Corti, A; Curnis, F (corresponding author), IRCCS San Raffaele Sci Inst, Tumor Biol & Vasc Targeting Unit, Div Expt Oncol, I-20132 Milan, Italy.

MOLECULAR PHARMACEUTICS, 2020; 17 (10): 3813

Abstract

The therapeutic index of cytokines in cancer therapy can be increased by targeting strategies based on protein engineering with peptides containing th......

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